Having a left hand drive (or as we Brit's call 'em - Wrong Hand Drive) car here in the UK can be a pain at times.
The most annoying things will be paying tolls, going through drive-thru area's (McDonalds etc).
I do most of my car driving on bigger roads anyway, so the overtaking issue isn't as bad for me. Plus I have a motorcycle for my r&r driving around.
I just love the 'Trep's though. I travel to the USA often, and I normally hire one. Have had one in LA, NYC and New Orleans (navigating it around the French Quarter was fun at times!), and have had several in San Francisco. For some reason, Thrifty seems only to have Gold ones!